Chloroquine phosphate

cas 50-63-5

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Product name:

Chloroquine Phosphate

Synonyms:

7-chloro-4-((4’-diethylamino-1-methylbutyl)amino)quinolinediphosphate

CAS#:

50-63-5

Molecular Formula:

C18H26ClN3.2(H3PO4);C18H32ClN3O8P2

Molecular weight:

515.87

Molecular Structural:

515.87.JPG

Appearance:

White crystalline powder

Specification:

98.5% - 101%

Package:

25kg/drum

Storage:

Store in the original container, protected from light, in a dry, cool place

Shelf life:

5 years


Description

Chloroquine phosphate is a 4-aminoquinoline antimalarial, which can inhibit the nucleic acid synthesis of plasmodium schizonts, interfere with the growth and reproduction of plasmodium, and have an efficient killing effect on plasmodium schizonts.

 

Chloroquine phosphate has antiviral activity. Chloroquine phosphate has shown very good activity against novelcoronavirus in in vitro studies.

Function

Chloroquine phosphate has a strong binding force to nucleoprotein, and its negatively charged 7-chloro group on the quinoline ring is close to the 2-amino group on DNA guanine, so that chloroquine is inserted between the two strands of the DNA double helix. Forms a complex with DChemicalbookNA, thereby preventing DNA replication and RNA transcription. Chloroquine can also inhibit the incorporation of phosphoric acid into the DNA and RNA of Plasmodium. Due to the reduced synthesis of nucleic acids, it interferes with the reproduction of Plasmodium.

Application

This product is used for the treatment of falciparum, vivax and p. malariae which are sensitive to chloroquine.And can be used for the inhibition and prevention of malaria symptoms.Also can be used to treat intestinal amoebiasis, connective tissue disease, photosensitive diseases (such as erythema) and so on. The drug was found to be effective in inhibiting novelcoronavirus infection at the cellular level. 

 

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TAG:   Chloroquine phosphate

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