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Benfotiamine Powder
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Benfotiamine Powder

Benfotiamine Powder

Benfotiamine is a fat-soluble derivative of thiamine (Vitamin B1). It is a chemical substance synthesized by modifying the structure of thiamine. First developed in Japan in the 1960s, it was designed to address the low bioavailability of thiamine.
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Product Details ofBenfotiamine Powder

product-780-311Question

What is Benfotiamine used for?

 

Out of these compounds, benfotiamine is best known and most widely used and studied for its anti-inflammatory, antioxidative and other beneficial effects. It has been investigated as a treatment for diabetic complications, neurodegenerative diseases and inflammatory complications.

 

Product-information

Product name:

Benfotiamine Powder

Synonyms:

N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-S-benzoate dihydrogen phosphate

CAS:

22457-89-2

According as:

ChP2020

Storage:

In a cool and dry environment away from light

Shelf life:

24 months from date of production

Origin:

China

Certificate:

ISO9001/FSSC 22000

 

Specification

Test Item

Standard

Test Methods

Product name:

Benfotiamine

Visual

Appearance:

White crystalline powder

ChP2020

Assay:

98.0%-102.0%

ChP2020

Identification:

The retention time of main peak is
accordant with that of Benfotiamine RS

ChP2020

Melting point:

NLT 198℃

ChP2020

Loss on drying:

NMT 5.0%

ChP2020

Clarity and color of solution:

Colorless to light yellow clear solution

ChP2020

Chloride:

NMT 0.053%

ChP2020

Sulphate:

NMT 0.011%

ChP2020

Heavy metals:

NMT 20.0 ppm

ChP2020

Cadmium:

NMT 1.0 ppm

ChP2020

Arsenic:

NMT 1.0 ppm

ChP2020

Lead:

NMT 0.5 ppm

ChP2020

Mercury:

NMT 0.3 ppm

ChP2020

Bulk density:

NLT 0.35 g/ml

Internal Control

Thiamine:

NMT 0.1%

ChP2020

Benzoic acid:

NMT 0.1%

ChP2020

Total impurities:

NMT 0.1%

ChP2020

Total Plate Count:

NMT 1,000 CFU/g

ChP2020

Yeast & Mold:

NMT 100 CFU/g

ChP2020

E.Coil:

Negative

ChP2020

Salmonella:

Negative

ChP2020

Staphylococcus Aureus:

Negative

ChP2020

 

application

  1. Dietary Supplements: As a fat-soluble derivative of vitamin B1, Benfotiamine has higher bioavailability and can penetrate tissue barriers efficiently. It is often added to supplements targeting anti-fatigue, blood sugar management, and nerve protection, suitable for groups such as diabetic patients, people on high-sugar diets, and the elderly. It can be formulated as a single-ingredient product or combined with other nutrients.
  2. Pharmaceutical Field: Benfotiamine is mainly used for the prevention and treatment of vitamin B1 deficiency, as well as the adjuvant treatment of diabetic peripheral neuropathy, mild cognitive impairment, polyneuritis and other diseases. It can block abnormal metabolic pathways, protect nerves and blood vessels, and requires strict raw material purity.
  3. Functional Food Field: Benfotiamine can be used as a nutritional fortifier added to sports nutrition foods, formula foods for the middle-aged and elderly, meal replacement powders and other products, helping supplement vitamin B1 required for human metabolism and enhancing the nutritional functionality of foods.
  4. Cosmetics Field: Benfotiamine is used in a niche market for high-end anti-aging and repairing skin care products. Taking advantage of its antioxidant properties, it helps reduce skin damage caused by free radicals, improves dullness and aging problems, and provides gentle protection for the skin.

 

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  • Absorption Rate: Benfotiamine is lipid-soluble, which allows it to pass through cell
  • membranes considerably more easily than water-soluble thiamine. It uses passive diffusion to get around the active transport constraint.
  • Cellular Delivery: Benfotiamine is absorbed intact and transformed inside cells into thiamine pyrophosphate (TPP), the active form used by your body for energy metabolism and neuronal function. It works especially well on nerves, eyes, kidneys, and blood vessels.
  • Retention Time: Long retention time in the body. Benfotiamine's fat solubility enables storage in adipose tissue and cells, extending the half-life to 12-24 hours.
  • High Safety: Benfotiamine's fat solubility ensures milder in vivo metabolism. Even at high doses (over 500mg/day), gastrointestinal reactions are rarely reported, and it does not interfere with the absorption of other B-complex vitamins.

 

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Q1: Is Benfotiamine the same as vitamin B1?

A1: Benfotiamine is similar to thiamine (vitamin B1), but is absorbed by the body better than thiamine. The body changes benfotiamine to thiamine. Since the body absorbs benfotiamine better than thiamine, benfotiamine can increase how much thiamine is in the body.

 

Q2: Is Benfotiamine good for eyes?
A2: Benfotiamine may help reduce risk of chronic eye disease. Symptoms include loss of light perception and severe vision loss. Supplementing with benfotiamine could help improve optic neuropathy symptoms more quickly than thiamine supplements due to benfotiamine's increased absorption rate.

 

Q3: What is the best time of day to take Benfotiamine?
A3: It is recommended to take Benfotiamine with food to enhance its absorption, given its fat-soluble nature. This can also help minimize potential gastrointestinal discomfort some users might experience when taking supplements on an empty stomach.

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