Mecobalamin (Vitamin B12)
Are Mecobalamin and B12 the same?
Methylcobalamin (MeCbl), an active form of Vitamin B12, has been increasingly dominating the nutritional formulation market. In India, it is available as parenteral, oral, and sublingual formulations, either alone or in combination with other B-group vitamins (multivitamin formulations).
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Product name: |
Mecobalamin (Vitamin B12) |
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Synonyms: |
Methyl-5,6-dimethylbenzimidazolylcobalamin; Vitamin B12 |
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According as: |
JP XVIII and in house standard |
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Solvent used: |
Acetone |
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Packing: |
0.5kg/bag,4kg/tin;0.5kg/tin |
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Storage: |
In a cool and dry environment away from light |
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Shelf life: |
36 months from date of production |
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Origin: |
China |
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Certificate: |
ISO9001/FSSC 22000 |
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Production process: |
It undergoes processes including methyl transfer reaction, high centrifugal separate,evaporation and concentration,adsorption and desorption of macroporous resin columns,crystalline crude solution,crystallization,seiving,drying and blending,inner package and metal detection. |
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Test Item |
Standard |
Test Method |
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Product name: |
Mecobalamin (Vitamin B12) |
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Appearance: |
Dark red crystals or crystalline powder |
JP Monograph Visual method |
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Identification： |
UV: Compare the spectrum with the reference spectrum, Both spectra exhibit similar intensities of absorption at the same wavelengths. |
JP Monograph/JP <2.24> |
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Cobalt:Meets JP requirement |
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Clarity and color of solution: |
The solution is clear and red color |
JP Monograph |
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Related substances: |
Each area of the peaks other than mecobalamin is not more than 0.5% of the peak area of mecobalamin |
JP Monograph |
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The total area of the peaks other than mecobalamin is not more than 2.0% |
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Water: |
NMT 11.5% |
JP Monograph/JP <2.01> |
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Assay (on the anhydrous basis): |
98.5%-101.0% |
JP Monograph/JP <2.01> |
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Acetone: |
NMT 5,000 ppm |
JP Monograph/JP<2.48> |
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Total aerobic microbial count: |
NMT 1,000 cfu/g |
JP Monograph |
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Total combined yeasts/mould count: |
NMT 100 cfu/g |
In house/ (GC)SOP-QC-004-04-06 |
- Pharmaceutical Fields: Mecobalamin is a commonly used ingredient in the pharmaceutical sector for addressing health issues related to vitamin B12 deficiency, and it is also applied to assist with certain peripheral nerve-related discomfort.
- Healthcare Supplement: Mecobalamin is a regular raw material for dietary supplements. It is often used to provide nutritional supplementation for specific groups such as vegetarians, the elderly, and pregnant people, and is also combined with folic acid, vitamin B6, etc., to make compound nutritional products for targeted populations.
- Special Food Field: Mecobalamin can be added to special foods, including infant formula, special medical purpose diets, and plant-based foods, to meet the nutritional needs of different special groups for this ingredient.
- Cosmetics Field: In the cosmetics field, mecobalamin is incorporated into repairing skincare products, which can help improve the basic skin condition and alleviate some common minor issues related to the skin barrier.
- No Need for In Vivo Conversion: Mecobalamin is an active form of vitamin B12 that can be directly utilized by the human body. It does not require metabolic conversion in the liver, enabling rapid absorption and utilization, and avoids vitamin B12 utilization disorders in some populations caused by the lack of conversion enzymes.
- Strong Targeting Ability: Mecobalamin has high affinity for nerve tissue, can directly participate in the synthesis and repair of nerve myelin, is more suitable for the research and development of products targeting nervous system maintenance, and can act precisely on physiological processes related to the blood system.
- Wide Applicable Population: Mecobalamin is particularly suitable for vegetarians, the elderly, people with weak gastrointestinal function, and pregnant women. These groups may have limitations in B12 absorption or conversion, and mecobalamin can be supplemented directly to reduce the risk of latent deficiency.
- Good Stability: Mecobalamin maintains good component stability under conventional health product production processes (such as tableting and capsule filling) and storage conditions. It also has strong compatibility when compounded with nutrients like folic acid and vitamin B6, and is not prone to component antagonism.
- High Safety: Mecobalamin has the same physiological activity as the natural vitamin B12 in the human body. Excessive intake can be naturally excreted through urine, and its safety for long-term appropriate supplementation is superior to that of some inactive B12 preparations, making it suitable as a raw material for long-term dietary supplements.
Q1: Is Mecobalamin good for nerves?
A1: Mecobalamin is a form of vitamin B12 that is found in higher amounts around neurons. It plays a role in biochemical reactions that increase the production of DNA, RNA, and proteins. Mecobalamin also helps regenerate nerves and promotes the synthesis of lecithin, which aids in the repair of damaged nerves.
Q2: Can I take Mecobalamin daily?
A2: Methylcobalamin is a naturally occurring form of vitamin B12. It is a kind of vitamin supplement. For best bioavailability and absorption of methylcobalamin, a daily dose is recommended to make it more beneficial or effective.
Q3: What is the difference between Mecobalamin and Cyanocobalamin?
A3: Methylcobalamin is the active form of B12 used directly in the body, whereas cyanocobalamin is a synthetic form that the body converts into active B12. Methylcobalamin is often preferred for its direct bioavailability, while cyanocobalamin is commonly used in supplements due to its stability and cost-effectiveness.
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