PDRN Powder (Polydeoxyribonucleotide)
What is PDRN?
Polydeoxyribonucleotide (PDRN) is a substance extracted from salmon DNA that is compatible with our human cells, it helps stimulate cell regeneration for newer and younger looking skin.It improves the skin's regenerative capability,skin tone and texture by balancing oil and moisture levels in the skin.
What are the scientifically validated efficacies of PDRN?
Extensive preclinical and clinical studies have confirmed three core efficacies of PDRN:
Tissue Repair & Wound Healing: Significantly accelerates the healing of diabetic foot ulcers, pressure ulcers, burn injuries, skin graft donor sites, and corneal epithelium.
Anti-inflammatory Activity: Effectively reduces inflammation in models of arthritis, periodontitis, and experimental colitis.
Anti-ischemic Effects: Improves blood flow recovery and provides tissue protection in peripheral artery occlusive disease and testicular ischemia-reperfusion injury.
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Product Name: |
PDRN Powder | |
| INCI Name: | SODIUM DNA | |
| Source: | Salmon sperm DNA | |
| Manufacturing technique: | Multiple displacement amplification (MDA) | |
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Description:: |
White or off white powder | |
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Hyperchromicity: |
NLT 30.0% | |
| PH value: | 6.4 | |
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Loss on drying:: |
8.5% | |
| Molecular weight | 50,000 to 300,000 Daltons | |
| Assay(UV): | 103.0% | |
| Applications: | It can be used for cosmetics such as masks, creams, lotions, etc. | |
| Certification: | ISO9001/FSSC22000 | |
Basic Properties of Raw Material: |
Basic Characteristics: | Polymer/Mixture |
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Source of raw materials: |
Animal (Direct Source) | |
| Production Method: | Solvent Extraction | |
Purpose of Use in Cosmetics: |
Skin Protectant, Skin Conditioner | |
Recommended Usage Level in Cosmetics: |
Leave-on Cosmetic Products: | 0.02%~0.5% |
| Rinse-off Cosmetic Products: | 0.02%~0.5% | |
| Formula Incompatibility: | Avoid contact with strong acids, strong alkalis, and strong oxidizing agents. | |
| Other Usage Restrictions: | Not for use by individuals allergic to nucleic acid products. | |
| Solubility: | Slightly soluble in water; insoluble in ethanol. | |
| Production Process Overview: | Thawing and mincing of salmon milt → Tissue homogenization with 0.14 M NaCl and 0.015 M sodium citrate solution → Centrifugation to remove supernatant → Enzymatic hydrolysis to release DNP → SDS treatment for protein removal → Sedimentation centrifugation to remove precipitate → Alcohol precipitation → Dissolution in TE buffer, followed by filtration and sterilization → Ultrafiltration for desalting → Lyophilization. | |
Functions: Repair, remove acne marks, anti-aging, anti-wrinkling.
PDRN activates adenosine A2A receptors, promoting cytokine release to exert anti-inflammatory effects and repair damaged cells. Activation of A2A receptors stimulates proliferation of osteoblasts, fibroblasts, and adipocyte precursor cells while rejuvenating aged and damaged cells. Concurrently, VEGF release occurs upon receptor activation, enhancing blood circulation and accelerating cellular regeneration.
PDRN promotes collagen regeneration
The experimental results showed that compared with the control group, type I and type ll collagen weresignificantly increased in PDRN group, indicating that PDRN can promote collagen synthesis.
PDRN has antioxidant properties
The results showed that PDRN could inhibit oxidative stress in skin cells in a dose-dependent manner.
Key Quality Parameters |
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|---|---|---|
| Test Item | Wuhan Healthdream | A Certain PDRN Manufacturer |
| Protein Impurity Content: | < 0.5% | 2.2% |
| Nucleic Acid Hyperchromic Effect: | > 35% | 3.4% |
| Bacterial Endotoxins: | For Topical Use: < 3.5 EU/mg For Injection: < 0.5 EU/mg |
> 3.5 EU/mg Does not meet specification |
Note: A higher hyperchromic effect indicates that the PDRN possesses a greater proportion of the natural double-helix structure, resulting in stronger biological activity. Conversely, a low hyperchromic effect suggests a low content of the natural double-helical structure in the product, leading to reduced or even absent activity.
Our Advantages:
FAQ
1.Why is PDRN particularly suitable for solving facial skin problems?
PDRN is a product obtained by rigorously purifying and sterilizing fish sperm DNA, which has a similarity of up to 98% to human DNA. It has significant effects in skin repair.
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