Alpha-Ketoglutarate
Description
Natural Fermentation AKG
-Principle and characteristics: Extracting from natural materials using biological enzyme technology, encapsulating with liposomes
to improve absorption efficiency and protect from decomposition.
-Advantages: Avoiding chemical synthesis by products, high absorption efficiency.
- Disadvantages:High production cost, complex process, limited output.
question
How does 99% Alpha-Ketoglutarate (AKG) serve as a key driver for cellular longevity and metabolic health?
As a core intermediate in the tricarboxylic acid (TCA) cycle, 99% Alpha-Ketoglutarate (AKG) directly fuels cellular energy production, supporting optimal ATP generation. Additionally, it is involved in epigenetic regulation and the activation of autophagy. These processes help clear damaged cells and support cellular repair mechanisms, thereby promoting healthy cellular aging and maintaining metabolic homeostasis.
Specification
|
Product name: |
Alpha-Ketoglutaric Acid(AKG) |
|
Synonyms: |
2-Oxoglutaric acid; 2-Oxopentanedioic acid ; alpha-Ketoglutaric acid |
|
Molecular Formula: |
C5H6O5 |
|
Molecular Weight: |
146.10 |
|
CAS Registry Number: |
328-50-7 |
|
Appearance: |
White or almost white crytalline power |
|
Assay: |
NLT 99 %,by HPLC |
|
Bulk Density: |
0.4g/mL～0.7g/mL |
|
Loss on Drying: |
NMT 0.5 % |
|
Residue on Ignition: |
NMT 0.5 % |
|
Total Heavy Metals: |
NMT 10 ppm |
|
Lead (Pb): |
NMT 2.0 ppm |
|
Arsenic (AS): |
NMT 3.0 ppm |
|
Cadmiun(Cd): |
NMT 2.5 pppm |
|
Mercury(Hg): |
NMT 1.5 pppm |
|
Total plate count: |
NMT 1,000 CFU/G |
|
Yeast&Mold: |
NMT 100.0 CFU/G |
|
Salmonella: |
Negative |
|
E.coli: |
Negative |
|
Staphylococcus aureus: |
Negative |
Function
*Participate in energy metabolism
AKG is a key intermediate product in the tricarboxylic acid cycle. The tricarboxylic acid cycle is the core metabolic pathway for cells to obtain energy, which occurs in mitochondria. AKG participation in this process ensures efficient production of
energy(ATP) by cells, providing power for various physiological activities of cells, maintaining normal cellular functions, and slowing down the aging process of cells due to insufficient energy.
*Optimizing mitochondrial function
Mitochondria are the "energy factories" of cells, and their function declines with age. AKG can optimize mitochondrial function, including improving mitochondrial respiratory function and maintaining mitochondrial structural integrity. Through these methods, the energy metabolism efficiency of cells is enhanced, mitochondrial aging is delayed, and the overall cellular aging process is positively affected
*Affects epigenetic regulation
AKG can also play a role at the epigenetic level, regulating epigenetic processes such as DNA methylation and histone modification. In terms of DNA methylation, DNA methylation is the addition of methyl groups to specific DNA regions under the action of DNA methyltransferases (DNMTs). AKG can regulate the activity of DNMTs, thereby affecting DNA methylation levels. For example, it may reduce the methylation of certain aging related gene promoter regions, allowing these genes to be expressed and exert anti-aging.
Application
1.Dietary Supplements & Sports Nutrition: As a core ingredient, it is widely used in the development of healthy aging, cellular energy metabolism, and sports nutrition supplements. It helps support muscle recovery and promotes healthy protein metabolism.
2.Pharmaceuticals & Clinical Care: Utilized as a biochemical reagent, drug carrier, and liver function testing reagent, it serves as a supportive nutritional ingredient to help maintain the body's nutritional status during recovery periods. It is also incorporated into formulations designed to support neurological balance.
3.Cosmetics & Personal Care: As a safe and eco-friendly active ingredient, it is frequently incorporated into skincare products and personal care items, such as deodorants.
4.Food Industry & Agriculture: In the food sector, it is used as a nutritional fortifier and flavor enhancer. In agriculture, it serves as a plant growth regulator that helps enhance crop resilience against environmental stressors, such as drought.
FAQ
Q1: What is the core mechanism of action of 99% Alpha-Ketoglutarate (AKG) in the human body?
A: AKG is a key intermediate in the tricarboxylic acid (TCA) cycle within mitochondria, the cell's "powerhouse." It directly participates in cellular energy (ATP) synthesis, promotes amino acid metabolism and protein synthesis, and helps the body clear toxic ammonia generated during metabolism. Thus, it plays a central role in supporting vitality, promoting healthy aging, and maintaining overall metabolic health.
Q2: What are the specific benefits of AKG in sports nutrition and anti-aging?
A: In sports nutrition, AKG helps reduce ammonia accumulation after exercise, delays muscle fatigue, and supports muscle recovery and growth following high-intensity training. In the field of healthy aging and longevity, recent research suggests that AKG may promote an extended healthspan through epigenetic modulation. Additionally, as an essential cofactor in collagen synthesis, it helps support the health of skin, joints, and bones.
Q3:How to choose the safest and most stable AKG?
A:The AKG produced by enzymatic fermentation technology has higher safety, purity, biological activity, and better absorption;Another type is AKG combined with calcium salts, which has high stability and synergistic nutritional supplementation effects, and can further improve and enhance absorption efficiency.
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