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Dipeptidyl Peptidase IV (DPP-IV)
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Dipeptidyl Peptidase IV (DPP-IV)

Dipeptidyl Peptidase IV (DPP-IV)

Our dipeptidyl peptidase-IV (DPP-IV) is a serine protease with high purity and activity. DPP-IV specifically cleaves X-proline or X-alanine dipeptides from the N-terminus of various bioactive peptides, most notably glucagon-like peptide-1 (GLP-1), which plays a central role in glucose homeostasis and immune regulation. DPP-IV is an ideal ingredient for functional food and beverage applications, dietary supplements, and pharmaceutical research. Our products are produced in strict accordance with quality control protocols to ensure batch-to-batch consistency, purity, and efficacy, making them a reliable choice for manufacturers developing scientific health solutions.
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Product Details ofDipeptidyl Peptidase IV (DPP-IV)

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Question

What is dipeptidyl peptidase-IV?

Dipeptidyl Peptidase IV (DPP-IV)is a key functional ingredient for managing healthy blood sugar levels. It works by inhibiting the activity of the DPP-IV enzyme, thereby prolonging the action of endogenous incretin hormones (like GLP-1), which supports healthy glucose metabolism. It can be added to medical foods, meal replacement powders, healthy beverages, and yogurts.

 

Product-information

Product name:

Dipeptidyl peptidase IV (DPP-IV)

Source:

Aspergillus Niger fermentation

CAS No:

54249-88-6

Specification:

Food grade

Country of origin:

China

Appearance:

Taupe to light yellowish brown powder

Package:

25kg/Drum

Product feature:

High solubility, light taste, and good product compatibility

Stability:

The product has good stability at temperatures ≤40°C

Moisture:

< 7.00%

Enzyme activity:

>40,000 u/g

Applicable population:

Gluten intolerant

Application:

Premix with other enzyme for tablet and capsule

Certificate:

Cgmp, ISO, FSSC22000, Kosher, Halal

Shelf life:

24 months

Storage:

Store in cool and dry place protected from light, keep barrel close when not in use

 

Function Mechanism of Healthdream Dipeptidyl Peptidase IV

Dipeptidyl peptidase IV (DPP IV) can effectively cleave the peptide bonds of proline residues in proteins rich in proline. Celiac disease is a severe autoimmune disorder caused by an allergy to gluten (a protein found in wheat, barley, and rye), commonly occurring in genetically predisposed individuals. Celiac disease can cause damage to the small intestine. The breakdown of these proteins by DPP IV helps alleviate symptoms associated with gluten sensitivity and prevent further damage to the body.

 

Specification

Description

Taupe to light yellowish brown powder

USP 36

Odor & Taste

Characteristic odor and taste

USP 36

Moisture

NMT 7%

USP <921>

Identifiable Activity

Positive for Dipeptidyl Peptidase Activity

In-house

Dipeptidyl Peptidase

activity

>40 ppu/g

In-house

Total Bacteria Count

NMT 1,000 CFU/g

FDA BAM Online Ch. 3

Coliform Bacteria

NMT 30 CFU/g

FDA BAM Online Ch. 4

Molds and Yeasts

NMT 100 CFU/g

FDA BAM Online Ch. 18

E. coli

Absent

FDA BAM Online Ch. 4

Salmonella

Absent

FDA BAM Online Ch. 5

Staphylococcus aureus

Absent

FDA BAM Online Ch. 12

Pseudomonas aeruginosa

Absent

AOAC

Lead

NMT 3 ppm

USP <233>

Mercury

NMT 0. 1 ppm

USP <233>

Cadmium

NMT 1 ppm

USP <233>

Arsenic

NMT 1 ppm

USP <233>

 

application

As a core ingredient in dietary supplements, DPP-IV is often formulated into capsules, tablets, or powders, providing natural support options for individuals concerned about their blood sugar health.

In the field of functional foods and beverages (such as protein shakes, meal replacement bars, and fortified drinks), it can be used to optimize the peptide components involved in the digestion process.

In food processing (if regulations permit), it can be used to pretreat protein substrates to reduce the length of peptides that are difficult to decompose.

 

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Excellent specificity: Highly specific to substrates containing N-terminal X-Pro/Ala sequences, with high hydrolysis efficiency and low background interference.

Strict quality control: Each batch of products undergoes rigorous testing for activity, purity, and stability to ensure minimal differences between batches and reliable product quality.

Natural microbial fermentation: produced through the fermentation of specific non pathogenic microbial strains to meet the market's demand for natural biological fermentation ingredients.

Wide application prospects: With the increasing awareness of health, the demand for functional foods, health supplements, and pharmaceuticals continues to grow.

 

2025103116120032023

Q1: What is the difference between DPP-IV and regular proteases?
A: Standard proteases can cleave many peptide bonds, but they are inadequate when dealing with sequences rich in proline. Dipeptidyl peptidase-IV (DPP-IV) has proline specificity and can trim the N-terminal dipeptide, where the second residue is proline (or alanine), thereby accelerating the decomposition of recalcitrant food peptides.

 

Q2: What is the function of DPP-IV enzyme?
A: Dipeptidyl peptidase 4 (DPP4) plays an important role in glucose metabolism. It is responsible for degrading intestinal insulin-like substances, such as glucagon like peptide-1 (GLP-1). In addition, DPP-4 can also bind to adenosine deaminase

 

Q3: Is DPP-IV a gluten enzyme?
DPP-IV (dipeptidyl peptidase IV) is a digestive enzyme that helps break down gluten. This means it can help reduce some discomfort associated with eating gluten. If you feel a bit overweight, bloated, bloated, or uncomfortable after dining out, DPP IV may be helpful.

 

Q4: Can it be used for protein powder or RTD?
A: Yes, but we need to verify the process conditions. High temperatures (such as UHT) may cause enzyme inactivation; Consider post-processing addition or microencapsulation.
 

 

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