Dipeptidyl Peptidase IV (DPP-IV)


What is dipeptidyl peptidase-IV?
Dipeptidyl Peptidase IV (DPP-IV)is a key functional ingredient for managing healthy blood sugar levels. It works by inhibiting the activity of the DPP-IV enzyme, thereby prolonging the action of endogenous incretin hormones (like GLP-1), which supports healthy glucose metabolism. It can be added to medical foods, meal replacement powders, healthy beverages, and yogurts.

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Product name: |
Dipeptidyl peptidase IV (DPP-IV) |
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Source: |
Aspergillus Niger fermentation |
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CAS No: |
54249-88-6 |
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Specification: |
Food grade |
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Country of origin: |
China |
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Appearance: |
Taupe to light yellowish brown powder |
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Package: |
25kg/Drum |
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Product feature: |
High solubility, light taste, and good product compatibility |
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Stability: |
The product has good stability at temperatures ≤40°C |
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Moisture: |
< 7.00% |
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Enzyme activity: |
>40,000 u/g |
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Applicable population: |
Gluten intolerant |
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Application: |
Premix with other enzyme for tablet and capsule |
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Certificate: |
Cgmp, ISO, FSSC22000, Kosher, Halal |
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Shelf life: |
24 months |
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Storage: |
Store in cool and dry place protected from light, keep barrel close when not in use |
Function Mechanism of Healthdream Dipeptidyl Peptidase IV
Dipeptidyl peptidase IV (DPP IV) can effectively cleave the peptide bonds of proline residues in proteins rich in proline. Celiac disease is a severe autoimmune disorder caused by an allergy to gluten (a protein found in wheat, barley, and rye), commonly occurring in genetically predisposed individuals. Celiac disease can cause damage to the small intestine. The breakdown of these proteins by DPP IV helps alleviate symptoms associated with gluten sensitivity and prevent further damage to the body.

|
Description |
Taupe to light yellowish brown powder |
USP 36 |
|
Odor & Taste |
Characteristic odor and taste |
USP 36 |
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Moisture |
NMT 7% |
USP <921> |
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Identifiable Activity |
Positive for Dipeptidyl Peptidase Activity |
In-house |
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Dipeptidyl Peptidase activity |
>40 ppu/g |
In-house |
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Total Bacteria Count |
NMT 1,000 CFU/g |
FDA BAM Online Ch. 3 |
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Coliform Bacteria |
NMT 30 CFU/g |
FDA BAM Online Ch. 4 |
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Molds and Yeasts |
NMT 100 CFU/g |
FDA BAM Online Ch. 18 |
|
E. coli |
Absent |
FDA BAM Online Ch. 4 |
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Salmonella |
Absent |
FDA BAM Online Ch. 5 |
|
Staphylococcus aureus |
Absent |
FDA BAM Online Ch. 12 |
|
Pseudomonas aeruginosa |
Absent |
AOAC |
|
Lead |
NMT 3 ppm |
USP <233> |
|
Mercury |
NMT 0. 1 ppm |
USP <233> |
|
Cadmium |
NMT 1 ppm |
USP <233> |
|
Arsenic |
NMT 1 ppm |
USP <233> |

As a core ingredient in dietary supplements, DPP-IV is often formulated into capsules, tablets, or powders, providing natural support options for individuals concerned about their blood sugar health.
In the field of functional foods and beverages (such as protein shakes, meal replacement bars, and fortified drinks), it can be used to optimize the peptide components involved in the digestion process.
In food processing (if regulations permit), it can be used to pretreat protein substrates to reduce the length of peptides that are difficult to decompose.

Excellent specificity: Highly specific to substrates containing N-terminal X-Pro/Ala sequences, with high hydrolysis efficiency and low background interference.
Strict quality control: Each batch of products undergoes rigorous testing for activity, purity, and stability to ensure minimal differences between batches and reliable product quality.
Natural microbial fermentation: produced through the fermentation of specific non pathogenic microbial strains to meet the market's demand for natural biological fermentation ingredients.
Wide application prospects: With the increasing awareness of health, the demand for functional foods, health supplements, and pharmaceuticals continues to grow.

Q1: What is the difference between DPP-IV and regular proteases?
A: Standard proteases can cleave many peptide bonds, but they are inadequate when dealing with sequences rich in proline. Dipeptidyl peptidase-IV (DPP-IV) has proline specificity and can trim the N-terminal dipeptide, where the second residue is proline (or alanine), thereby accelerating the decomposition of recalcitrant food peptides.
Q2: What is the function of DPP-IV enzyme?
A: Dipeptidyl peptidase 4 (DPP4) plays an important role in glucose metabolism. It is responsible for degrading intestinal insulin-like substances, such as glucagon like peptide-1 (GLP-1). In addition, DPP-4 can also bind to adenosine deaminase
Q3: Is DPP-IV a gluten enzyme?
DPP-IV (dipeptidyl peptidase IV) is a digestive enzyme that helps break down gluten. This means it can help reduce some discomfort associated with eating gluten. If you feel a bit overweight, bloated, bloated, or uncomfortable after dining out, DPP IV may be helpful.
Q4: Can it be used for protein powder or RTD?
A: Yes, but we need to verify the process conditions. High temperatures (such as UHT) may cause enzyme inactivation; Consider post-processing addition or microencapsulation.
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